What are the difficulties in high resistance measurements?

High resistance measurements can be challenging due to several factors, including noise and interference from external sources, which can significantly impact accuracy. Additionally, the contact resistance at the junctions between the measurement probes and the material being tested can introduce errors. The need for high voltage to drive a measurable current can also lead to dielectric breakdown in materials or components. Finally, maintaining stable environmental conditions, such as temperature and humidity, is crucial, as these factors can affect resistance readings.