Methadone, by far. Methadone is one of the strongest and longest acting opiates. Although it does not give the most intense "high" do not let that fool you, because it is powerful. 20mg's of methadone for a person who has never done it can last up to 2 days. Many people think because they have other opiate tolerance that they can take a high dose of methadone, but this is not the case. I have had friend die from methadone intoxication when he took about 60mg's on his first try.
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