Which man would most likely support the secession of the Southern states from the Union?

A man who would most likely support the secession of the Southern states from the Union would be a staunch defender of states' rights and an advocate for slavery, such as John C. Calhoun. He believed that individual states had the right to govern themselves and make decisions free from federal interference. Additionally, many Southern plantation owners and politicians of the time shared this perspective, prioritizing their economic interests and social structures over national unity.