Can you take alleve hydromorphone and aspirin together?

First you need to check your hydrocodone medication to see if it already contains aspirin (acetylsalicylic acid or ASA).Hydrocodone is almost always dispensed as a tablet with either a dose of ASA (aspirin) or a dose of APAP (acetaminophen) included. If your hydrocodone tablet already contains aspirin, then you don't want to take any additional aspirin. You could take a dose of acetaminophen with it, but it probably wouldn't offer any additional benefit. If your hydrocodone is compounded with APAP, then you can take aspirin with it. The hydrocodone/APAP compound manages pain and fever, while the aspirin adds the benefit of reducing inflammation somewhat.