What organs acts most directly to remove old red blood cells frm circulation?

The organs that act most directly to remove old red blood cells from circulation are the spleen and the liver. The spleen filters the blood, identifying and destroying aged or damaged red blood cells, while the liver processes the byproducts of red blood cell breakdown, such as bilirubin. Together, these organs play a crucial role in maintaining healthy blood composition and recycling iron for new red blood cell production.