How do replace the fuel filter on a Ford F-250 gas pickup?

To replace the fuel filter on a Ford F-250 gas pickup, first, relieve the fuel system pressure by removing the fuel pump relay and starting the engine until it stalls. Next, locate the fuel filter, typically found along the frame rail or near the fuel tank. Disconnect the fuel lines from the filter using a line removal tool, then remove the old filter and install the new one, ensuring the flow direction matches the markings on the filter. Finally, reconnect the fuel lines, replace the fuel pump relay, and start the engine to check for leaks.