Do you take Benadryl allergy medicine in the morning or at night?

Any time of day, but note how many hours you must wait before taking it again on the package. In addition, Benadryl can cause drowsiness (it is also sold under the name of Unisom as a sleeping pill, actually), so don't take it with alcohol and don't take it when you will be driving or operating dangerous machinery or equipment--even in the kitchen.