When will it be safe to get rid of wasp nest in the bird box?

It's generally safest to remove a wasp nest in a bird box during late evening or early morning when wasps are less active. Wait until late fall or early winter when wasps have died off or left the nest for the season. Always wear protective clothing and consider using a professional pest control service for safety. Avoid removing the nest during the warmer months when wasps are active and can become aggressive.