Amphetamine is primarily metabolized and cleared from the body by the liver through enzymatic processes. The main enzymes involved are cytochrome P450 enzymes, particularly CYP2D6. Additionally, amphetamine is excreted through the kidneys, with urine pH affecting its elimination; acidic urine can enhance excretion. Overall, the half-life of amphetamine varies, but it typically ranges from 9 to 14 hours in healthy individuals.
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