Can Karnovsky's Fixative used with TEM?

Yes, Karnovsky's Fixative can be used with Transmission Electron Microscopy (TEM). It is a dual-fixative solution that typically contains formaldehyde and glutaraldehyde, which helps preserve cellular ultrastructure and provides good contrast for electron microscopy. However, samples must be properly post-fixed with osmium tetroxide to enhance membrane contrast and prevent shrinkage, ensuring optimal visualization under TEM.