Staphylococcus aureus is not typically present in the blisters of scalded skin syndrome because the disease is caused by exfoliative toxins produced by the bacteria, rather than the bacteria themselves. These toxins lead to the separation of the epidermis, resulting in blister formation. The blisters are filled with clear fluid and do not harbor the bacteria, as the toxins act locally and can cause damage without direct infection. Consequently, the absence of S. aureus in the blisters is consistent with the pathophysiology of the condition.
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