What are the main difficulties that might arise in trying to establish a new business?

I'd like to start with "start up cost"
1) How big is the store front?
2) Is it a retail outlet?
3) is it in a good location?
4) what is your advertising costs you're willing to spend?
5) INSURANCE COST?
6) inventory and storage?
7) employee and staff costs IE( with holdings for soc. sec., unemployment ins,
Medicaid, employee taxes, workman's compensation, etc, )
These are all factors that come into play. I don't know what type of business you are planning to open, but in any business there are at least one or two of the above mentioned factors to consider.
Have you ever thought about an on-line business?
I have no idea what your age is, but I would like to ask you a question, if you could turn back the years, knowing what you know now, would you have gotten into EBay or Amazon? If your answer is yes, then we need to get together and talk. I won't take up anymore of your time, but if you are interested, feel free too contact me anytime.
Hope I've been of some help, and good wishes in your endeavor.
George Johnson
george.henry.johnson@gmail.com