Is Under light microscopy aggregations of Guarnieri bodies relevant to a laboratory diagnosis of smallpox?

Yes, the presence of Guarnieri bodies is relevant to the laboratory diagnosis of smallpox. These are cytoplasmic inclusions found in infected cells and are characteristic of the variola virus, which causes smallpox. Identifying these bodies under light microscopy can help confirm the diagnosis, especially when combined with other laboratory techniques. However, due to the historical eradication of smallpox, such diagnoses are now rare.