Why concomitant use of two or more NSAID contraindicated?

Concomitant use of two or more NSAIDs is contraindicated due to the increased risk of adverse effects, particularly gastrointestinal bleeding, ulcers, and kidney damage. Using multiple NSAIDs does not enhance pain relief but significantly raises the potential for toxicities. Additionally, overlapping mechanisms of action can lead to an accumulation of side effects without added therapeutic benefit. Thus, careful management and monitoring are essential when prescribing these medications.