Who were the two most persecuted groups during the 1800?

During the 1800s, two of the most persecuted groups were Indigenous peoples and African Americans in the United States. Indigenous populations faced violent displacement and cultural assimilation due to westward expansion and policies like the Indian Removal Act. African Americans, particularly those enslaved in the South, endured systemic oppression, violence, and dehumanization under slavery, while free Black individuals faced discrimination and limited rights in both the North and South.