To replace the oxygen sensor on a 2006 GMC Sierra, first ensure the engine is cool and disconnect the battery. Locate the oxygen sensor, which is typically found on the exhaust manifold or downstream in the exhaust system. Use a socket wrench with an O2 sensor socket to carefully unscrew the old sensor, then install the new sensor by threading it in and tightening it securely. Finally, reconnect the battery and clear any diagnostic trouble codes if necessary.
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