How long to bake large catfish fillets?

To bake large catfish fillets, preheat your oven to 375°F (190°C). Place the fillets on a greased baking sheet or in a baking dish, and bake for about 20 to 25 minutes, or until the fish flakes easily with a fork and reaches an internal temperature of 145°F (63°C). For added flavor, you can season the fillets before baking, and consider broiling them for the last few minutes for a crispy top.