When was alteplase first used in ischaemic stroke?

Alteplase was first approved for use in ischaemic stroke in the United States in 1996 after the results of the National Institute of Neurological Disorders and Stroke (NINDS) trial demonstrated its efficacy in improving outcomes when administered within three hours of symptom onset. This marked a significant advancement in the treatment of ischaemic stroke, establishing alteplase as a standard therapy for eligible patients.