Can methotrexate cuse Angular cheilitis

Methotrexate can potentially contribute to angular cheilitis due to its effects on folate metabolism and immune function, which may lead to deficiencies that manifest as mouth sores or cracks at the corners of the lips. Additionally, the immunosuppressive nature of methotrexate may increase susceptibility to infections, including those that cause angular cheilitis. However, while methotrexate is not a direct cause, its side effects can create conditions conducive to the development of this condition. If you suspect a link, it's important to consult a healthcare provider for proper assessment and management.