Can cephalosporin be used for syphilis?

Cephalosporins are not the first-line treatment for syphilis; the recommended antibiotic for syphilis is penicillin. While some studies have suggested that certain cephalosporins may have some efficacy against Treponema pallidum, the bacteria that causes syphilis, they are not standard treatment options. Therefore, penicillin remains the preferred and most effective treatment.