The 2005 Ford Econoline E-350 with a 5.4L engine typically averages around 10 to 12 miles per gallon (MPG) in city driving and about 13 to 16 MPG on the highway. Fuel economy can vary based on factors such as load, driving conditions, and maintenance. Overall, it is not known for high fuel efficiency, as it is designed primarily for cargo capacity and heavy-duty usage.
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