Can you safely give your car having comprehensive and collision coverage to your friend who has a drivers license but no insurance?

If you're asking if your friend can simply borrow your car occasionally, and you carry full coverage and liability on the car, then yes, you should be okay.

Car insurance follows the vehicle, so even if your friend has his own coverage and had an accident while driving your car, your insurance would still be primary.

If, however, you're talking about allowing your friend to drive the car all the time, on a daily and/or regular basis, you could face problems if you don't let your insurance carrier know that your friend is using the car all the time. This is because the premiums you pay are based on you as a driver, not your friend.