Can you put a 11-28 cassette with 53-39 chainring?

Yes, you can use an 11-28 cassette with a 53-39 chainring. This combination provides a good range of gears, allowing for both high-speed and easier climbing options. However, ensure that your derailleur can accommodate the range of the cassette and that your chain is compatible with the gear setup. Additionally, check for proper chain length to avoid shifting issues.