Portulaca is not difficult to kill with many common herbicides. Check the inside label. Purslane is closely related and usually listed. I think the main problem is that both seed so much. Even if you kill the plant, there are plenty of seed in the soil to germinate & ruin your landscape. Try a pre-emergent herbicide after killing the weeds. It can keep seeds from germinating.
Portulaca does root very shallow. Pulling young plants is your best way to go. Using heavy mulch or paper under mulch can help.
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