What is the best way to cook a heel of round roast to ensure it is tender and flavorful?

The best way to cook a heel of round roast to ensure it is tender and flavorful is to cook it low and slow at a low temperature, such as 275F, until it reaches an internal temperature of 135-140F for medium-rare. This method allows the meat to break down slowly, resulting in a tender and flavorful roast.