Why does pepsin not digest protein at temperatures above 60 degress Celsius?

Pepsin is an enzyme that functions optimally at a specific acidic pH and temperature range, typically around 37 degrees Celsius. At temperatures above 60 degrees Celsius, the enzyme's structure begins to denature, meaning its three-dimensional shape is altered. This denaturation reduces its ability to bind to and cleave protein substrates effectively, significantly impairing its digestive function. As a result, pepsin loses its activity at elevated temperatures.