Will phenergan make opiates work better?

Phenergan (promethazine) is an antihistamine that can enhance the effects of opioids, potentially leading to increased sedation and pain relief. It may also help mitigate some side effects of opiates, such as nausea. However, combining these medications should be done cautiously and under medical supervision, as it can increase the risk of respiratory depression and other adverse effects. Always consult a healthcare professional before mixing medications.