How should I properly pick up cats by their scruff to ensure their safety and comfort?

To properly pick up a cat by their scruff, gently grasp the loose skin on the back of their neck with one hand while supporting their hindquarters with the other hand. This mimics how a mother cat carries her kittens and can help keep the cat calm and secure. It's important to only lift the cat briefly and avoid putting too much pressure on their neck to ensure their safety and comfort.