Could poison ivy go into your blood steam?

Poison ivy itself cannot enter your bloodstream; it causes skin reactions through an allergic response to its oil, urushiol. When urushiol comes into contact with the skin, it can lead to rashes, blisters, and inflammation, but it does not penetrate the skin deeply enough to enter the bloodstream. The reaction is localized to the area of contact, although severe allergic reactions can lead to systemic symptoms in some cases. It's important to wash the skin thoroughly after exposure to reduce the risk of a reaction.