Can predisone cause false positive THC test?

Yes, prednisone can potentially lead to false positive results for THC (tetrahydrocannabinol) on drug tests. This is primarily due to the way some immunoassay tests are designed, which may cross-react with certain medications, including corticosteroids like prednisone. However, confirmation tests, such as gas chromatography-mass spectrometry (GC-MS), can differentiate between prednisone and THC. If there are concerns about drug testing, it's advisable to inform the testing facility about any medications being taken.