Both demerol and percocet are opioids, meaning they have opium alkaloids as their base. As far as potency goes, the oxycodone in Percocet is stronger than the meperidine in Demerol. Taken orally, Demerol is only about one-third as strong as when given IV or in a muscle. Taken orally, oxycodone is about 50% stronger than morphine, which is many times stronger than meperidine.
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