How far can a diesel semi tractor trailer go in a quarter tank of gas?

A diesel semi-truck typically has a fuel tank capacity of around 100 to 150 gallons. Assuming a quarter tank would be approximately 25 to 37.5 gallons, the fuel efficiency of a diesel semi averages around 6 to 8 miles per gallon. Therefore, a quarter tank could allow a semi to travel roughly 150 to 300 miles, depending on various factors such as load weight, terrain, and driving conditions.