What is unacceptable to disinfect the site prior to blood culture collection according to CLS?

According to the Clinical and Laboratory Standards Institute (CLSI), it is unacceptable to use alcohol alone to disinfect the site prior to blood culture collection. This is because alcohol does not effectively kill all pathogens, particularly some bacterial spores. CLSI recommends using a chlorhexidine-based antiseptic or iodine-based solution for proper skin disinfection before collecting blood cultures to ensure optimal contamination prevention.