Yes. Frontline/Frontline Plus is a topical flea and tick preventative. Prednisone is a steroid and has many uses in veterinary medicine as it is an anti-inflammatory. Quite often it is used to control Allergies in dogs, for pain relief, controlling inflammation, and in a number of other conditions.
These medications do not adversely interact with each other. However, with the use of any medication there is the risk of having a reaction. If there are any unusual side effects when using a medication prescribed by your veterinarian, let them know as soon as possible.
Prednisone, as useful as it is, can cause significant side effects if not used judiciously. Use it ONLY under the direction of your veterinarian and follow their directions explicitly.
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