Does aspartame cause severe kidney pain in those with phenylketonuria?

Aspartame is an artificial sweetener that contains phenylalanine, which can be harmful to individuals with phenylketonuria (PKU), a genetic disorder that impairs the body's ability to metabolize phenylalanine. However, there is no direct evidence linking aspartame consumption to severe kidney pain specifically in those with PKU. Individuals with PKU are advised to avoid phenylalanine, including aspartame, to prevent potential health complications. If kidney pain occurs, it is essential for individuals with PKU to consult a healthcare professional for proper evaluation and management.