How did Queen Isabella affect history?

Queen Isabella I of Castile played a pivotal role in shaping history through her support of Christopher Columbus's 1492 voyage, which led to the European discovery of the Americas. Her marriage to Ferdinand II of Aragon unified Spain, laying the groundwork for the Spanish Empire. Isabella also initiated the Spanish Inquisition, which aimed to consolidate Catholic orthodoxy in her realm, impacting religious and cultural dynamics in Europe. Her reign marked the beginning of Spain's rise as a global power during the Age of Exploration.