Charcot-Marie-Tooth disease (CMT) primarily affects the peripheral nerves, leading to muscle weakness and atrophy, especially in the feet and legs. It can cause sensory loss, resulting in decreased ability to feel pain or temperature changes, and may lead to foot deformities like high arches or hammertoes. Over time, individuals may experience difficulties with balance and coordination. The severity and specific symptoms can vary widely depending on the type of CMT.
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