What causes brown spot on palm of hands?

Brown spots on the palms of the hands are often caused by sun exposure, leading to a condition known as solar lentigines or age spots. Other potential causes include skin conditions like eczema or psoriasis, hormonal changes, or the effects of certain medications. Additionally, liver spots can develop as a result of aging and skin damage. If the spots change in appearance or cause concern, it's best to consult a healthcare professional for evaluation.