To replace staples in an Office Depot heavy-duty stapler, first, ensure the stapler is in the open position by pressing the lever or sliding the top back. Remove any remaining staples by pulling out the staple cartridge or emptying the tray if necessary. Insert a new strip of heavy-duty staples into the cartridge or tray, aligning it properly. Finally, close the stapler and test it to ensure it's working correctly.
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