By land area, according to the US Census Bureau from the 2000 Census, Coconino County, Arizona with a total area of 18,661.21 sq mi (48,332.3 km2) and a total land area of 18,617.42 sq mi (48,218.9 km2).
By population, according to the 2010 US Census, Cook County, Illinois is the largest with 5,194,675 people.
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