What does severe deficiency in thyroxine in early childhood result in?

Severe deficiency in thyroxine during early childhood can lead to cretinism, a condition characterized by stunted growth, intellectual disability, and developmental delays. It can also cause physical abnormalities, such as a short stature and delayed puberty. Additionally, the lack of thyroxine can affect various bodily functions, leading to issues with metabolism and overall health. Early detection and treatment are crucial to mitigate these effects.