To replace the radio in a 1997 Lexus ES300, start by carefully prying off the trim panel surrounding the radio using a flat tool to avoid damage. Remove the screws securing the radio and disconnect the wiring harness and antenna cable. Install the new radio by connecting the wiring harness and antenna, securing it with screws, and then reattach the trim panel. Ensure everything is properly connected and test the new radio before finalizing the installation.
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