The worst type of lupus is often considered to be systemic lupus erythematosus (SLE). SLE can affect multiple organ systems, including the kidneys, heart, and brain, leading to severe complications. Its unpredictable flare-ups and potential for serious damage make it particularly challenging to manage. Other forms of lupus, such as cutaneous lupus or drug-induced lupus, are generally less severe and primarily affect the skin or are triggered by medications.
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