Can you take Benadryl with Prozac?

Yes, you can generally take Benadryl (diphenhydramine) with Prozac (fluoxetine), but it's important to do so under the guidance of a healthcare professional. Both medications can cause sedation, and combining them may increase the risk of drowsiness and other side effects. Always consult your doctor or pharmacist for personalized advice and to ensure safety based on your specific health situation.