What horror movie has a girl in a wheelchair in a huge house?

The Horror movie you're thinking of is likely "Gerald's Game," based on the novel by Stephen King. In the film, a woman named Jessie is left alone in a remote house after her husband dies unexpectedly during a sexual game. While she is not in a wheelchair throughout the entire movie, there are significant elements of vulnerability and isolation that resonate with your description. The film explores themes of trauma and survival in a tense, confined setting.