Depends upon the species and locality. Pythons and boas that inhabit areas around water (such as water pythons, reticulated pythons, green anacondas, etc.), will often eat anything from rodents to small mammals (and big ones, in the cases of reticulated pythons and anacondas) to fish and crocodiles!
In captivity, you can feed your pythons and boas mice, rats, guinea pigs (not recommended due to a high percentage of fat), chicken, quails, rabbits, and fish.
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