How does estrogen and testosterone get into cells?

Estrogen and testosterone enter cells primarily through passive diffusion due to their lipophilic (fat-soluble) nature. Once inside the cell, these hormones bind to specific intracellular receptors, which then translocate to the nucleus to regulate gene expression. Additionally, some cells may have transport proteins that facilitate the uptake of these hormones. Overall, their entry into cells is crucial for mediating their physiological effects.