What are the side effects of taking prednisone and codeine together?

Taking prednisone and codeine together can increase the risk of certain side effects. Prednisone, a corticosteroid, may lead to increased blood sugar levels, mood changes, and gastrointestinal issues. Codeine, an opioid, can cause drowsiness, constipation, and respiratory depression. Combining these medications may heighten the risk of gastrointestinal problems and exacerbate drowsiness or sedation, requiring careful monitoring by a healthcare provider.