Can you take oxycodone and librium together?

You can, but it's risky. They're both extremely potent sedatives and each medication enhances the effect of the other exponentially which can make it easy to accidentally overdose.

Additionally, they're both Central Nervous System depressants and when you combine them together you can get respiratory depression, which means your brain stops sending the signals to your body to breathe and you suffocate.

People mix the two types of medication (opiates and benzodiazepines) frequently for a better high, but it's like playing with matches.