What are the best settings for shooting portraits with a Canon T3i?

When shooting portraits with a Canon T3i, use a wide aperture (around f/2.8 to f/5.6) for a blurred background, set a low ISO (around 100-400) for sharpness, and adjust the white balance to match the lighting conditions. Consider using natural light or a soft external flash for flattering lighting. Experiment with different angles and compositions to capture the subject's personality.